Analyzing the Secondary Metabolites and Pharmacological Activities of Solanum ferox: A Systematic Review
DOI:
https://doi.org/10.33394/hjkk.v13i4.17007Keywords:
Solanum ferox, Secondary Metabolites, PharmacologyAbstract
This study explores Solanum ferox, also known as Solanum lasiocarpum Dunal, as a rich source of secondary metabolites in herbal medicine. The main objective of this article is to highlight the secondary metabolites contained in S. ferox. The methodology employed is a Systematic Literature Review, following the PRISMA guidelines, which analyzes 8 selected articles published from 2018 onwards. These articles were sourced from Google Scholar, PubMed, and Mendeley databases, focusing on studies related to the phytochemistry of this plant. the results of the document analysis show Solanum ferox contains various compounds such as alkaloids, flavonoids, tannins, terpenoids, steroids, and saponins, which demonstrate significant potential in antioxidant, antibacterial, and anticancer activities. These results also indicate the possible structures of the identified compounds, providing a deeper understanding of their bioactivity. Moreover, this study highlights how the diverse phytochemical profile of Solanum ferox supports its traditional use in herbal remedies. These findings emphasize the importance of further research to optimize the utilization of Solanum ferox in the development of safe, effective, and sustainable herbal medicines.
References
Adawiah, A., Sukandar, D., & Muawanah, A. (2015). Aktivitas antioksidan dan kandungan komponen bioaktif sari buah namnam. Jurnal Kimia VALENSI, 1(2), 130–136.
Akhmadi, C., & Utami, W. (2022). Senyawa Fitokimia dan Aktivitas Farmakologi Family Basellaceae sebagai Obat Luka: A Narrative Review. Generics: Journal of Research in Pharmacy, 2(2), 77–85.
Anggoro, A. B. (2022). Perbandingan Kadar Total Flavonoid Ekstrak Etanol Buah Terong Ungu (Solanum melongena L.) dan Terong Asam (Solanum ferox L.) dengan Metode Spektrofotometri Visible. REPOSITORY STIFAR.
Artanti, A. N., & Lisnasari, R. (2018). Uji Aktivitas Antioksidan Ektrak Ethanol Daun Family Solanum Menggunakan Metode Reduksi Radikal Bebas DPPH. Journal of Pharmaceutical Science and Clinical Research, 2, 62–69.
Bae, H., Song, G., & Lim, W. (2020). Stigmasterol causes ovarian cancer cell apoptosis by inducing endoplasmic reticulum and mitochondrial dysfunction. Pharmaceutics, 12(6), 1–16. doi: 10.3390/pharmaceutics12060488
Balachandran, C., Emi, N., Arun, Y., Yamamoto, Y., Ahilan, B., Sangeetha, B., Duraipandiyan, V., Inaguma, Y., Okamoto, A., Ignacimuthu, S., Al-Dhabi, N. A., & Perumal, P. T. (2015). In vitro anticancer activity of methyl caffeate isolated from Solanum torvum Swartz. fruit. Chemico-Biological Interactions, 81–90.
Balentine, D. A., Dwyer, J. T., Erdman, J. W., Ferruzzi, M. G., Gaine, P. C., Harnly, J. M., & Kwik-Uribe, C. L. (2015). Recommendations on reporting requirements for flavonoids in research. American Journal of Clinical Nutrition, 101(6), 1113–1125. doi: 10.3945/ajcn.113.071274
Budiarto, E., Suparno, Kusumadati, W., Muliansyah, Mahrita, S., & Faridawaty, E. (2022). Sifat Fisikokimia Minuman Instant Terung Asam (Solanum ferox L) dengan Penambahan Dekstrin dan Variasi Suhu Pengeringan. Agrienvi: Jurnal Ilmu Pertanian, 16(1), 90–98. doi: 10.36873/aev.2022.16.1.90
Chidambaram, K., Alqahtani, T., Alghazwani, Y., Aldahish, A., Annadurai, S., Venkatesan, K., Dhandapani, K., Thilagam, E., Venkatesan, K., Paulsamy, P., Vasudevan, R., & Kandasamy, G. (2022). Medicinal Plants of Solanum Species: The Promising Sources of Phyto-Insecticidal Compounds. Journal of Tropical Medicine, 1–22. doi: 10.1155/2022/4952221
Diniyah, N., & Lee, S.-H. (2020). Komposisi senyawa fenol dan potensi antioksidan dari kacang-kacangan. Jurnal Agroteknologi, 14(01), 91–102.
Elmitra, E., Apriyanti, O., & Sepriani, T. L. (2019). Uji Efektivitas Antiinflamasi Ekstrak Etanol Daun Cabe Rawit (Solanum Frutescens. L) Pada Mencit Jantan (Mus Muscullus) Dengan Metode Induksi Caraagenan. Journal Academi Pharmacy Prayoga, 4(2), 1–13.
Ernawita, A. M. (2022). Fitokimia, Sifat Antibakteri dan Antioksidan serta Aktivitas Sitotoksik Ekstrak Etanol Daun Sirih Hijau. CV. Azka Pustaka. Retrieved from https://books.google.co.id/books?id=t2yuEAAAQBAJ
Firdaus, M., Prihanto, A. A., & Nurdiani, R. (2013). Tanaman Bakau: Biologi dan Bioaktivitas. Universitas Brawijaya Press. Retrieved from https://books.google.co.id/books?id=35tjDwAAQBAJ
Firmansyah, E. K., Sutirman, M., & Baihaqie, E. (2017). Kearifan Lokal dalam Pengobatan Tradisional Masyarakat Desa Lumbungsari Kecamatan Lumbung Kabupaten Ciamis. Metahumaniora, 7(1), 65–81.
Fransiska, A. N., Masyrofah, D., Marlian, H., Sakina, I. V., & Tyasna, P. S. (2021). Identifikasi senyawa terpenoid dan steroid pada beberapa tanaman menggunakan pelarut n-heksan. Jurnal Health Sains, 2(6), 733–741.
Halimatussakdiah, H., & Amna, U. (2016). Isolasi Senyawa Alkaloid Indol dari Ekstrak Akar Kopsia singapurensis Ridl (Apocynaceae). JURUTERA-Jurnal Umum Teknik Terapan, 3(02), 6–11.
Hardi, E. H., Nugroho, R. A., Kusuma, I. W., & Saptiani, G. (2021). Antiparasitic Activity of Single Solanum ferox Extract and Concoction with Zingiber zerumbet and Boesenbergia pandurata Extracts to Control Argulus sp. on Goldfish (Cyprinus carpio). Preprints, 2021120513.
Hazimah, Fadhli, H., & Fitriyah, D. (2023). Stigmasterol (Steroid) From Leaves of Solanum ferox L (Sour Eggplant) Plant. Al-Kimia, 11(1), 20–27. doi: 10.24252/al-kimiav11i1.35337
Hazimah, H, Azharman, Z., Yuharmen, Y., Rahyuti, V., & Afriliani, A. (2019). Antibacterial Activity of The Hexane Extract from Leaf of Plant Solanum Ferox L. Proceedings Of The Proceedings Of The 5Th Annual International Seminar On Trends In Science And Science Education, AISTSSE 2018, 18-19 October 2018, Medan, Indonesia.
Hazimah, Hazimah, Azharman, Z., Triwuri, N. A., & Jose, C. (2018). Phytochemical evaluation, antioxidant test from Solanum ferox plant L and Plectranthus amboinicus L. Jurnal Ains Dan Terapan Kimia, 12(2), 76–83.
Hazimah, Hazimah, Haiyul, F., Dina, F., Yuharmen, Y., & Widya, R. (2023). Isolation of Antioxidant and Antibacterial Compound from Solanum ferox L Leaves. BIO Web of Conferences, 70, 3007.
Helilusiatiningsih, N., Yunianta, Y., Harijono, H., Widjanarko, S. B., & Sujuti, H. (2019). Aktivitas Sitotoksik Fraksi Heksana Terung Pokak (Solanum torvum) terhadap Sel Kanker T47D. Jurnal Kedokteran Brawijaya, 30(4), 253–258. doi: 10.21776/ub.jkb.2019.030.04.4
Ibrahim, N. F., Zakaria, N. A., & Aris, F. (2022). Phytochemistry and Biological Activity of Terung Asam, Indigenous Fruit-Vegetables of Sarawak - A Review. Journal of Sustainability Science and Management, 17(2), 270–285. doi: 10.46754/jssm.2022.02.019
Kalalinggi, S. Y. (2024). In Vitro Activity of Ethanol Extract of Rimbang Fruit (Solanum ferox) as an Active Ingredient in Sunscreen Preparations. Indonesian Journal of Chemical Analysis (IJCA), 7(1), 72–81.
Kalalinggi, S. Y., Rasidah, R., & Yuliana, Y. (2024). In vitro activity of ethanol extract of rimbang fruit (Solanum ferox) as an active ingredient in sunscreen preparations. IJCA (Indonesian Journal of Chemical Analysis), 7(1), 72–81. doi: 10.20885/ijca.vol7.iss1.art8
Khandani, S. K., Mehrabani, M., Sharififar, F., Pardakhty, A., & Pournamdari, M. (2019). Development and validation of an RP-HPLC method for determination of solasodine, a steroidal alkaloid. Journal of Young Pharmacists, 11(1), 21.
Kousar, R., Naeem, M., Jamaludin, M. I., Arshad, A., Shamsuri, A. N., Ansari, N., Akhtar, S., Hazafa, A., Uddin, J., & Khan, A. (2022). Exploring the anticancer activities of novel bioactive compounds derived from endophytic fungi: mechanisms of action, current challenges and future perspectives. American Journal of Cancer Research, 12(7), 2897.
Kumar, R., Khan, M. I., & Prasad, M. (2019). Solasodine: A Perspective on their roles in Health and Disease. Research Journal of Pharmacy and Technology, 12(5), 2571–2576.
Lajira, M. M., & Lister, I. N. E. (2019). Uji Antibakteri Ekstrak Buah Takokak (Solanum Torvum Swartz) Terhadap Pertumbuhan Bakteri Propionibacterium Acnes. BIOLINK (Jurnal Biologi Lingkungan Industri Kesehatan), 6(1), 73–79. doi: 10.31289/biolink.v6i1.2237
Mahmudah, R., Baharuddin, M., & Sappewali, S. (2016). Identifikasi isolat bakteri termofilik dari sumber air panas Lejja, Kabupaten Soppeng. Al-Kimia, 4(1), 31–42.
Makmur, M. (2019). Pengaruh Pemotongan Pucuk Apikal Dengan Pemberian Pupuk Fermentasi Kompos Limbah Kakao Terhadap Pertumbuhan Dan Produksi Tanaman Terong Ungu (Solanum melongena L). Journal TABARO Agriculture Science, 3(2), 386–393.
Meyer, R. S., Bamshad, M., Fuller, D. Q., & Litt, A. (2014). Comparing medicinal uses of eggplant and related Solanaceae in China, India, and the Philippines suggests the independent development of uses, cultural diffusion, and recent species substitutions. Economic Botany, 68, 137–152.
Mukhriani, M., Rusdi, M., Arsul, M. I., Sugiarna, R., & Farhan, N. (2019). Kadar fenolik dan flavonoid total ekstrak etanol daun anggur (Vitis vinifera L). Ad-Dawaa’Journal of Pharmaceutical Sciences, 2(2).
Nofita, D., & Dewangga, R. (2021). Optimasi perbandingan pelarut etanol air terhadap kadar tanin pada daun matoa (Pometia pinnata JR & G. Forst) secara spektrofotometri. Chimica et Natura Acta, 9(3), 102–106.
Noor, T., Kusuma, I. W., & Rosamah, E. (2021). Penelusuran Fitokimia dan Bioaktivitas dari Tumbuhan Terung Asam (Solanum ferox Linn). Prosiding SIKMA 8, 144–155.
Nugrahani, R., Andayani, Y., & Hakim, A. (2016). Skrining fitokimia dari ekstrak buah buncis (Phaseolus vulgaris L) dalam sediaan serbuk. Jurnal Penelitian Pendidikan Ipa, 2(1).
Nugroho, W., Rosmainar, L., & Toepak, E. P. (2023). Skrining Fitokimia dan Uji Antioksidan Menggunakan Metode DPPH Pada Ekstrak Metanol Buah Terung Asam Besar (Solanum Ferox Linn). Jurnal Crystal : Publikasi Kimia Dan Terapannya, 5(1).
Nurmaulawati, R., Studi Farmasi, P., Tinggi Ilmu Kesehatan Bhakti, S., Andani, Y., Tinggi Ilmu Kesehatan Bhakti Husada Mulia, S., Kunci, K., Aktivitas Antibakteri, U., Ranti Hijau, B., & Coli, E. (2024). Uji Antibakteri Ekstrak Buah Ranti Hijau (Solanum nigrum L) Terhadap Escherichia coli dan Staphyloccus aureus. 3(3). Retrieved from http://e-journal.lppmdianhusada.ac.id/index.php/PIPK
Pondini, D. A., Abriyan, E., Sevianti, E., Pitaloka, L., & Laelasari, T. (2023). Literatur Review: Analisis Kandungan Saponin Pada Daun Leunca (Solanum Nigrum L) Menggunakan Spektrofotometri Infra Red. Comserva: Jurnal Penelitian Dan Pengabdian Masyarakat, 02(09), 1610–1615.
Pramushinta, I. A. K. (2021). Kimia Organik. Jakad Media Publishing.
Prasetyo, P., Duryat, D., Riniarti, M., Hidayat, W., & Maryono, T. (2023). Pemanfaatan mangrove sebagai tumbuhan obat oleh masyarakat (Studi kasus di Desa Bumi Dipasena Utama Kabupaten Tulang Bawang Provinsi Lampung). ULIN: Jurnal Hutan Tropis, 7(2), 153–160. doi: 10.32522/ujht.v7i2.10443
Prasiddha, I. J., Laeliocattleya, R. A., Estiasih, T., & Maligan, J. M. (2016). The potency of bioactive compounds from corn silk (Zea mays L.) for the use as a natural sunscreen: a review. Jurnal Pangan Dan Agroindustri, 4(1), 40–45.
Priamsari, M. R., & Krismonikawati, R. A. (2019). Uji Daya Antiinflamasi Ekstrak Etanolik Kulit Terong Belanda (Solanum betaceum, Cav.) Pada Mencit Jantan yang Diinduksi Karagenin. Jurnal Ilmu Farmasi Dan Farmasi Klinik (JIFFK), 16(2), 86–92. Retrieved from www.unwahas.ac.id/publikasiilmiah/index.php/ilmufarmasidanfarmasiklinik
Putri, P. A., Chatri, M., & Advinda, L. (2023). Karakteristik saponin senyawa metabolit sekunder pada tumbuhan. Jurnal Serambi Biologi, 8(2), 252–256.
Raduan, S. Z., Khalid, K. N. A., Jihek, M. F. A., Ganasan, S., Salim, U. S., & Aziz, M. W. H. A. (2019). Anticariogenic properties of Solanum ferox L. ethanol extract. Annals of Dentistry University of Malaya, 26, 22–29.
Rahman, Z. A., Zaidan, M. W. A. M., Othman, A. N., Ahmad, M. A., Simoh, S., & Ismail, M. A. H. (2019). Optimizing Extraction of Phenolics and Flavonoids from Solanum ferox Fruit. Natural Science, 11(04), 99–105. doi: 10.4236/ns.2019.114011
Rizkita, A. D., Dewi, S. A., Wibowo, E. A. P., & Maulana, I. (2021). Isolasi dan Identifikasi Saponin dari Ekstrak Leunca (Solanium ningrum L) Secara Spektrofotometri Infra Merah. Jurnal Ilmiah Sains, 166–169.
Savitri, A. (2016). Tanaman Ajaib Basmi Penyakit dengan TOGA. Depok: Bibit Publisher.
Singh, R., Sharma, R., Soren, P., Mal, G., & Singh, B. (2019). Extraction and detection of saponin-enriched fractions from different plants of North-western Himalayas, India. Journal of Pharmacognosy and Phytochemistry, 8(3), 3817–3820.
Suryelita, S., Etika, S. B., & Kurnia, N. S. (2017). Isolasi Dan Karakterisasi Senyawa Steroid Dari Daun Cemara Natal (Cupressus Funebris Endl.). EKSAKTA: Berkala Ilmiah Bidang MIPA, 18(01), 86–94.
Syakirin, M. B., Mardiana, T. Y., & Efendi, R. (2022). Peningkatan Pertumbuhan dan Efisiensi Pemanfaatan Pakan Ikan Nila Salin (Oreochromis niloticus) dengan Penggunaan Ekstrak Terong Asam (Solanum ferox L.). Pena Akuatika : Jurnal Ilmiah Perikanan Dan Kelautan, 21(1), 86. doi: 10.31941/penaakuatika.v21i1.1775
Syarpin, S., Nugroho, W., & Rahayu, S. (2018). Uji fitokimia dan antioksidan ekstrak etanol buah terung asam (Solanum ferox L). Acta Pharmaciae Indonesia, 6(2), 46–50.
Syukriah, Azhari, Mhd. B., Ningrum, N. A., & Amira, S. (2022). Uji Fitokimia dan Antioksidan Ekstrak Etanol Buah Terung (Solanum lasiocarpum) dengan Metode DPPH. Jurnal Ilmiah Teknosains, 8(2), 8–13.
Waddell, A. R., Huang, H., & Liao, D. (2021). CBP/p300: critical co-activators for nuclear steroid hormone receptors and emerging therapeutic targets in prostate and breast cancers. Cancers, 13(12), 2872.
Yasser, M., Nurdin, M. I., Amri, A., Bangngalino, H., Angraini, N., & Said, R. U. (2022). Skrining Fitokimia Senyawa Flavonoid, Alkaloid, Saponin, Steroid Dan Terpenoid Dari Daun Kopasanda (Chromoloena odorata L.). Seminar Nasional Hasil Penelitian & Pengabdian Kepada Masyarakat (SNP2M), 7, 90–94.
Zhao, H., Zhang, X., Wang, M., Lin, Y., & Zhou, S. (2021). Stigmasterol simultaneously induces apoptosis and protective autophagy by inhibiting Akt/mTOR pathway in gastric cancer cells. Frontiers in Oncology, 11, 1–11. doi: 10.3389/fonc.2021.629008.
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